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What Are Psychedelic Drugs?

Psychedelic drugs, also known as hallucinogenic drugs or simply hallucinogens, are a group of substances that are usually use recreationally to change and enhance sensory perceptions, thought processes, and energy levels, and to facilitate spiritual experiences. They include chemicals, such as LSD, and plants, such as peyote.

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Psychedelics are often smoked (and inhaled), eaten, or brewed into tea. Use of hallucinogens goes back centuries in many cultures, and some are still used in religious ceremonies to experience spiritual or heightened states of awareness.

Hallucinogens were used in psychotherapy in the 1960s, but this was halted for mainly political reasons until quite recently.2 Psychological research has since revived the use of psychedelics in experimental psychological treatment.

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These chemicals all bind to serotonin 5-HT2A receptors, which modulate the activity of key circuits in the brain involved with sensory perception and cognition, however the exact nature of how psychedelics induce changes in perception and cognition via the 5-HT2A receptor is still unknown, although the fact that psychedelics reduce default mode network activity and increased connectivity between regions in the brain as a result is likely one of the most relevant pharmacological mechanisms underpinning the psychedelic experience, particularly ego death.

The psychedelic experience is often compared to non-ordinary forms of consciousness such as those experienced in meditation, mystical experiences, and near-death experiences, which also appear to be partially underpinned by altered default mode network activity.

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N, N-Dimethyltryptamine is a chemical substance that occurs in many plants and animals and which is both a derivative and a structural analog of tryptamine. It can be consumed as a psychedelic drug and has historically been prepared by various cultures for ritual purposes as an entheogen

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